Abstract Lon is a conserved AAA+ (ATPases associated with diverse cellular activities) proteolytic machine that plays a key regulatory role in cells under proteotoxic stress. Lon-mediated proteolysis can be stimulated by either the unfolded or specific protein substrates accumulated under stress conditions. However. the molecular basis for this substrate-controlled proteolysis remains... https://www.roneverhart.com/Donitsirauta-MDI-Donut-900/